interact to affect the survival of airborne viruses in aerosols

Does being cold increase your chances of catching the common cold "Everyone knows" a scary statement that you get "a cold" from being cold. Now it seems to be a fact that you don't, because you get a cold from a (rhino)virus, not from the temperature. But is there any correlation between temperature and disease? I've seen claims that "cold lowers your immune system", and stuff like that, but no real evidence. As soon as you look into scientific research about this, you get claims that the correlation is not causation, because in the winter people spend more time inside (close to one another) for instance. (See for instance this article) On the other hand and I know this is a really bad form of reasoning I think if I'd go outside in the freezing cold wearing nothing but some summer pants, I'd not come out of that after a couple of hours like a happy camper. Is this non sense, or is there some correlation between being cold (or even undercooled?) and disease? If so, how does this work? And while we're at it, there's even more data on the flu. rhinoviruses] occurs at an intermediate RH [relative humidity] of 40 70% (Arundel et al. 1986). Also, it is important to note that temperature and RH will always interact to affect the survival of airborne viruses in aerosols. [Edit: In my initial answer I suggested that being cold doesn't make a difference to you. That's not quite true. It does seem to increase susceptibility to infection, though of course the point is that you do need to be exposed to a virus; you don't get a cold just from being cold.] While temperature may have an effect Mens Puma Repli Cat III on your susceptibility to infection, it also has an effect on the survival of the virus outside your body. They prefer colder (less humid) environments. This does Mens Puma Rodalban XC Shoes mean you're more likely to catch a cold when it's cold, because the virus is more likely to survive and be transmitted. I'm wary of the virus' relation to temperatures (= I think it's wrong). No matter how cold it is outside, and no matter how Mens Puma Complete Shoes little clothing you wear, your body temperature will never be anywhere near 23 let alone 6 And I also don't see how these temperatures influence the virus' spread. Humidity yes. Cold weather? No. If the virus didn't survive (substantially) warmer climates, it couldn't survive in our bodies. In summary, I'm pretty sure the answer is wrong. Konrad Rudolph Mar 7 '11 at 18:40 This review partly Mens Puma Engine Cat Shoes contradicts the conclusion Mens Puma Ferrari Shoes in Solus' answer, that "being cold doesn't seem to make a difference to you". According to the review, it's does. However, Solus' answer is mainly concerned with influenza which is somewhat different from the rhinovirus so while his answer may actually be true, it almost certainly doesn't Mens Puma Suede shoes apply to the common cold. This isn't undisputed there is also some evidence to other causes (notably Eccles (2002) and Brenner al. (1999)). But most of the evidence points this way. Furthermore, the study by Eccles actually proposes a mechanism which isn't that much different from the one above. Ooh, interesting. What I see contradicted is Solus' claim Women's Puma Michael Schumacher Women's Puma Lazy Insect Shoes that "being cold doesn't seem to make a difference to you" (I'll edit to make this clearer). As for my comment below Solus' answer, I'd like to know what you find unclear: I don't have to provide a basis for my assertion, the onus is on the other side to substantiate their claim. In fact I'm not convinced in the case of influenza either. Just to clear matters up: I do acknowledge that temperature influences virus survivability. But only if it surpasses our body temperature (otherwise it couldn't flourish in us, but fever does kill virus infections). And I do acknowledge that a virus' optimal working temperature is below our body temperature but this is irrelevant for infectivity / spread since aerosol borne virii are not active. They need a host cell to become active. A virus in itself has no metabolic activity. Konrad Rudolph Mar 9 '11 at 11:25 Temperature dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells (Ellen F. Foxman, doi: 10.1073/pnas.1411030112)To gain insight into the mechanism of temperature dependent growth, we compared the transcriptional response of Women's Puma Shoes primary mouse airway epithelial cells infected with rhinovirus at 33 C vs. 37 C. Mouse airway cells infected with mouse adapted rhinovirus 1B exhibited a striking enrichment in expression of antiviral defense response genes at 37 C relative to 33 C, which correlated with significantly higher expression levels of type I and type III IFN genes and IFN stimulated genes (ISGs) at 37 C. Temperature dependent IFN induction in response to rhinovirus was dependent on the MAVS protein, a key signaling adaptor of the RIG I like receptors (RLRs). Stimulation of primary airway cells with the synthetic RLR ligand poly I:C led to greater IFN induction at 37 C relative to 33 C at early time points poststimulation and to a sustained increase in the induction of ISGs at 37 C relative to 33 C. Recombinant type I IFN also stimulated more robust induction of ISGs at 37 C than at 33 C. Genetic deficiency of MAVS or the type I IFN receptor in Cheap Puma Shoes infected airway cells permitted higher levels of viral replication, particularly at 37 C, and partially rescued the temperature dependent growth phenotype. These findings demonstrate that in mouse airway cells, rhinovirus replicates preferentially at nasal cavity temperature due, in part, to a less efficient antiviral defense response of infected cells at cool temperature.